Endocrine Abstracts

The aim of the study was to compare efficacy and tolerability of systemic corticotherapy alone to corticotherapy combined with orbital radiotherapy in severe active Graves’ ophthalmopathy. We studied 905 patients, aged 35–73 years (mean 58.2 ±12), with clinical activity score above 4 and ATA class 3c to 6. Therapeutic outcome was assessed by change in ophthalmopathy index. For 4 weeks all subjects received corticotherapy: 869 - oral prednisone 60–100 mg dai...

It is believed that differentiated thyroid tumors (DTC) metastasize via different pathways: papillary carcinoma (PTC) usually via lymphatic spread whereas follicular cancers (FTC) mainly hematogenously. However, the mechanism/s contributing to these tumors invasion is not fully understood.We examined the expression of lymphatic endothelial markers: Podoplanin (type-1 transmembrane mucin-like glycoprotein) and Prox1 (Prospero homeobox protein 1) in the PT...